Open Access

Radiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?

  • Alexis Vallard1,
  • Chloé Rancoule1,
  • Jean-Baptiste Guy1,
  • Avi Assouline2,
  • Alexander T. Falk3,
  • Pierre Auberdiac4,
  • Julien Langrand-Escure1,
  • Cyrus Chargari5 and
  • Nicolas Magné1Email author
Chinese Journal of Cancer201736:56

https://doi.org/10.1186/s40880-017-0224-5

Received: 25 October 2016

Accepted: 1 April 2017

Published: 14 July 2017

Dear editor,

Radiotherapy is a cornerstone in the management of anal or rectal cancer. Because elderly patients are often excluded from clinical trials, little is known about radiotherapy’s therapeutic index (efficacy/toxicity ratio) in the geriatric population [1]. Still, the ageing of population imposes the challenge to treat older cancer patients and probably to adjust their treatment [2]. A few studies reported data on radiation-induced toxicities in nonagenarian patients, but data on efficacy are still scarce. For rectal cancer, preoperative radiotherapy programs were suggested to be feasible in elderly patients [35], with a preference for short protocols without chemotherapy [4]. For anal cancer, the safety of radiochemotherapy was only reported in limited sets of elderly patients [6]. The objective of the present study was to report efficacy and toxicity data on the radiotherapy treatment of nonagenarian patients with anal or rectal cancer.

We analyzed the data of 34 nonagenarian patients with anal or rectal cancers: 27 (79.4%) with a rectal adenocarcinoma and 7 (20.6%) with an anal canal squamous cell carcinoma. At the time of irradiation treatment, the patients’ mean age was 92.7 years (standard deviation, 2.3 years). Before radiotherapy, 19 patients (55.9%) had an Eastern Cooperative Oncology Group Performance Status score of two or higher. Eleven patients (32.4%) were nursing home residents. Primarily, 16 patients (47.1%) were diagnosed with a locally advanced tumor (T3-4 or N1-3) and 6 (17.6%) with a metastatic disease. Seven patients (20.6%) underwent surgery before radiotherapy. Patient characteristics are shown in Table 1.
Table 1

Characteristics of 34 nonagenarians undergoing radiotherapy for anal or rectal carcinoma

Patient characteristic

No. of patients (%)

Gender

  Male

16 (47.1)

  Female

18 (52.9)

Performance status score

  0–1

14 (41.1)

  2–4

19 (55.9)

  Not reported

1 (3.0)

Living place

  Home

22 (64.7)

  Nursing home

11 (32.3)

  Not reported

1 (3.0)

Tumor characteristic

 Primary site

  Rectum

27 (79.4)

  Anal canal

7 (20.6)

 Stage

  Localized (T1-2N0)

7 (20.6)

  Locally advanced (T3-4 or N1-2)

16 (47.1)

  Metastatic

6 (17.6)

  Not reported

5 (14.7)

Three-dimensional conformal radiotherapy was used for curative (n = 13, 38.2%) and palliative intents (n = 21, 61.8%). The median delivered dose was 43.5 Gy (range 6.0–64.0 Gy), and the median biologically equivalent dose in 2.0 Gy fractions (EQD2) was 44.7 Gyα/β=10 (range 8.0–64.0 Gyα/β=10). The median number of fractions was 14 (range 1–32), and the median dose was 3.0 Gy per fraction (range 1.8–10.0 Gy per fraction), with 13 patients (38.2%) receiving a dose less than 2.5 Gy per fraction. Median total treatment duration was 3.0 weeks (range 0.1–6.6 weeks). No concomitant chemotherapy was administered.

In the entire cohort of 34 patients, 3 (8.8%) discontinued treatment: 2 because of patients’ noncompliance and 1 caused by an acute grade 3 toxicity. Eleven patients (32.3%) had a follow-up exceeding 6 months and were evaluated for late toxicity: 1 (2.9%) developed a grade 3–4 late fecal incontinence, 4 (11.8%) developed a grade 1–2 late toxicity (pelvic fibrosis, urinary incontinence, and fecal incontinence), and 6 (17.6%) did not report any late complication.

Median follow-up time was 13.4 weeks (range 0–142.0 weeks), with a follow-up less than 4.0 weeks for 8 patients (23.5%). At the last follow-up, tumor control (defined as stable disease, partial response, and/or complete response) was achieved for 18 patients (52.9%), including 10 of the 13 patients treated in curative intent and 8 of the 21 patients treated with palliative intent; tumor-related symptoms were controlled in 13 patients (61.9%) who underwent a palliative radiotherapy. Nine patients (26.5%) had died at the last follow-up; of them, 8 (88.9%) had disease progression.

In this study, we retrospectively assessed the safety and efficacy of radiotherapy for 34 nonagenarian patients with anal or rectal cancer. We observed only infrequent infield late toxicities (0% grade 5, 2.9% grade 3–4, and 11.8% grade 1–2). At the last follow-up, disease was controlled in 52.9% of the 34 patients. As expected, hypofractionated programs were widely used, since they reduce acute toxicities (in cell populations with a high turnover, such as mucosal membranes) and favor radiotherapy completion. Our results suggest that radiotherapy is feasible in nonagenarian patients with anal or rectal cancer, but geriatric assessment could probably decrease the probability of discontinuing treatment. Although no consensus exists regarding the role of brachytherapy in the management of anal cancer in patients 90 years of age or older, it should probably be considered a major option after external beam radiotherapy for patients with good physical condition, since very limited toxicities and good results on efficacy were suggested by recent studies [7, 8].

In conclusion, based on these real-life findings, radiotherapy may be feasible in nonagenarians patients, either with cure or palliative intent.

Declarations

Authors’ contributions

NM, CC, PA, AA, and CR conceived the study and participated in its design and coordination. AV, CR, JBG, and ATF performed the data acquisition. AV, CR, JBG, and ATF interpreted the data. NM, CR, and AV drafted the manuscript. NM reviewed the manuscript. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

Consent for publication

Not applicable.

Ethics approval and consent to participate

All participating institutions obtained Institutional Review Board approval to conduct the study.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Radiotherapy, Lucien Neuwirth Cancer Institute
(2)
Department of Radiotherapy, Porte De Saint Cloud Clinical Centre
(3)
Department of Radiation Oncology, Antoine Lacassagne Centre
(4)
Department of Radiotherapy, Claude Bernard Private Hospital
(5)
Department of Radiotherapy, Val-De-Grâce Military Hospital

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