Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy
© Liu et al. 2016
Received: 4 June 2015
Accepted: 4 August 2015
Published: 11 January 2016
Recently, studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal cancer. The purpose of this study was to evaluate a novel prognostic scoring system—DA score (combination of preoperative plasma D-dimer and serum albumin levels)—and analyze the association between survival of patients with esophageal squamous cell carcinoma (ESCC) and their Glasgow prognostic score.
In this retrospective study, preoperative biochemical markers and clinicopathologic factors in 260 ESCC patients treated with transthoracic esophagectomy were reviewed. According to receiver operating characteristic analysis, the cutoff values of D-dimer and albumin were defined as 0.5 μg/mL and 43.8 g/L, respectively. Patients with high D-dimer levels (≥0.5 μg/mL) and low albumin levels (<43.8 g/L) were assigned a score of 2, those with only one of the two abnormalities were assigned a score of 1, and those with neither of the two abnormalities were assigned a score of 0.
ESCC patients with a DA score of 0, 1, and 2 numbered 55, 116, and 89, respectively. Survival analysis showed that patients with a DA score of 2 had lower overall survival (OS) rates than those with DA scores of 1 and 0 (37.1% vs. 52.6% and 76.4%, P < 0.001); similar findings were observed for disease-free survival (DFS) rates (32.6% vs. 44.8% and 67.3%, P < 0.001). In addition, the predictive value of the DA score was also significant in patients with stages I–IIA and stages IIB–IV ESCC. Multivariate Cox regression analyses indicated that hazard ratios (HRs) for predicting OS of patients with DA scores 1 and 2 were 2.25 (P = 0.010) and 3.14 (P < 0.001), respectively, compared with those with a DA score of 0, and HRs for predicting DFS of patients with DA scores of 1 and 2 were 1.86 (P = 0.023) and 2.68 (P < 0.001), respectively, compared with those with a DA scores of 0.
Our study suggests that preoperative DA scores are notably associated with postoperative survival of ESCC patients.
Esophageal cancer (EC) is the eighth most common cancer worldwide and the sixth leading cause of death due to cancer . In China, the predominant histological type of EC is esophageal squamous cell carcinoma (ESCC), which accounts for 90% of ECs [2–4]. Despite multidisciplinary treatments that have been developed for ESCC, including surgical resection and neoadjuvant chemoradiation therapy, transthoracic esophagectomy remains the primary therapeutic strategy for locoregional ESCC [5–7]. Unfortunately, even after surgical resection, ESCC patients still have a high postoperative recurrence rate and poor prognosis, with only a 5-year survival rate ranging 26.2%–49.4% . Therefore, identifying a simple and instructive indicator that could identify ESCC patients with high risk of tumor recurrence and poor prognosis is urgently needed.
To date, clinical stages, pathologic findings, and performance statuses have been considered the predominant prognostic factors in patients with common solid tumors. However, clinical staging is often inaccurate despite the use of high-resolution computed tomography (CT), and definition of performance status is sometimes subjective [9, 10]. Recently, the Glasgow prognostic score (GPS), which is based on C-reactive protein (CRP) and albumin levels as well as reflects inflammation and nutritional status, was used as a prognostic indictor for numerous cancers . However, some studies indicated that systemic inflammation and malnutrition are not significant in operable ESCC patients, leading to decreased clinical application of GPS . Therefore, it is imperative to identify a novel prognostic scoring system that can improve the clinical outcome of ESCC patients.
In previous studies, coagulation abnormalities were commonly seen in patients with malignant tumors [13–15]. Systemic activation of blood coagulation and procoagulant changes were associated with angiogenesis, tumor cell invasion and progression, and metastatic spreading . D-dimer, which is an end-degradation product of fibrin, indicates the activation of hemostasis and the hypercoagulable state. Elevated D-dimer levels were observed in acute venous thromboembolism, pregnancy, infectious diseases, surgery, as well as cancers . Moreover, recent studies showed that elevated D-dimer levels predicted poor prognosis in various types of cancer, including breast cancer, lung cancer, ovarian cancer, and EC [16, 18]. Therefore, we hypothesized that the combination of D-dimer and albumin, which reflects malnutrition and poor survival in cancer patients [19–21], may provide a simple and objective prognostic scoring system for ESCC patients. In this study, we devised a novel prognostic scoring system, called the DA score (combination of D-dimer and albumin levels), and analyzed the clinical significance of the DA score for predicting the prognosis of ESCC patients who underwent transthoracic esophagectomy.
In this study, the data of 260 ESCC patients who underwent transthoracic esophagectomy between December 2004 and December 2010 in Sun Yat-sen University Cancer Center, Guangzhou, China were analyzed retrospectively. The criteria for case selection were as follows: (1) pathologic diagnosis of primary squamous cell carcinoma; (2) no history of preoperative adjuvant therapy; and (3) preoperative plasma D-dimer levels, serum albumin levels, and serum CRP levels obtained within 1 week before surgery. The following data were also recorded for all patients: age, sex, tumor diameter, tumor location, TNM stage, T category, N category, pathologic grade, history of hepatitis B virus infections, and family history of cancer. TNM classification was evaluated using the 6th edition of the Union for International Cancer Control staging. This study was approved by the medical ethics committee of Sun Yat-sen University Cancer Center, and informed consent was obtained from all patients.
D-dimer, albumin, and CRP measurement
As a part of clinical routine examinations, pretreatment plasma D-dimer levels, serum albumin levels, and CRP levels were measured 24 h to 1 week before surgery. Plasma D-dimer values were analyzed by a latex-enhanced immunoturbidimetric assay and a Sysmex CA 7000 system (Sysmex Corporation, Japan) according to the manufacturer’s instructions. Serum albumin levels and CRP levels were measured by using a Hitachi 7600-020 automatic biochemical analyzer (Hitachi, Japan). The optimal cutoff values of D-dimer and albumin in our study were verified using Youden’s index (YI) from the receiver operating characteristic (ROC) curve for ESCC prediction. The survival status was inserted into the YI to define the cutoff value as described by Huang et al.  and Liu et al. . A high level of preoperative plasma D-dimer was defined as ≥0.5 μg/mL, and a low level of preoperative serum albumin was defined as <43.8 g/L.
D-dimer and albumin (DA) score
ESCC patients with high D-dimer levels (≥0.5 μg/mL) and low albumin levels (<43.8 g/L) were assigned a score of 2, those with only one of the two biochemical abnormalities were assigned a score of 1, and those with neither of the two biochemical abnormalities were assigned a score of 0.
GPS was defined as described previously . Specifically, patients with low CRP (<10 mg/L) and high albumin levels (≥35 g/L) were assigned a score of 0, those with one of the two biochemical abnormalities were assigned a score of 1, and those with both high CRP levels and low albumin levels were assigned a score of 2.
Postoperative follow-up was performed by using gastroscopy and CT scanning every 3–6 months for the first 3 years, then annually until death or the end of the present study. In total, 260 ESCC patients were followed up for 2–91 months, with a median follow-up time of 40.5 months and a median survival time of 35 months (1–91 months). The last scheduled follow-up was on April 20, 2015. Overall survival (OS) was defined as the interval from the date of surgery to the date of death from any causes. Disease-free survival (DFS) was defined as the interval from the time of surgery to the date of local relapse or distant metastasis.
Statistical analysis was performed using the SPSS 16.0 software package (SPSS, Chicago, IL, USA). The Chi square test was used to assess the association between the DA scores and clinicopathologic variables of ESCC patients. OS and DFS curves were plotted by using the Kaplan–Meier method and evaluated by using the log-rank test. Univariate and multivariate survival analyses were performed by using the Cox regression model. Differences were considered statistically significant when the P value was <0.05.
Preoperative DA score and clinicopathologic variables in 260 patients with ESCC
No. of patients
Score 0 (n = 55)
Score 1 (n = 116)
Score 2 (n = 89)
Tumor size (cm)
1 + 2
3 + 4
Association between preoperative DA scores and clinicopathologic characteristics of ESCC
In the total study population, the median preoperative plasma D-dimer level was 0.5 (25th–75th percentile: 0.3–0.7) μg/mL, and the median preoperative serum albumin level was 43.1 (25th–75th percentile: 40.7–45.0) g/L. Of the 260 patients, 138 (53.1%) showed elevated preoperative D-dimer levels (≥0.5 μg/mL), and 156 (60.0%) showed decreased preoperative albumin levels (<43.8 g/L). Also of the 260 patients, 55 (21.2%) had a preoperative DA score of 0, 116 (44.6%) had a preoperative DA score of 1, and 89 (34.2%) had a preoperative DA score of 2 (Table 1). The association between preoperative DA scores and postoperative clinicopathologic characteristics is shown in Table 1. Older patients had higher preoperative DA scores than younger patients (P < 0.001), whereas patients with a family history of EC had lower preoperative DA scores (P = 0.032).
Association between preoperative DA scores and the survival of ESCC patients
Univariate Cox regression analysis for survival of ESCC patients
HR (95% CI)
HR (95% CI)
Tumor size (cm)
1 + 2
3 + 4
Glasgow prognostic score
Multivariate Cox regression analysis for survival in ESCC patients
HR (95% CI)
HR (95% CI)
Glasgow prognostic score
In the present study, we developed a novel prognostic scoring system, DA score, based on plasma D-dimer and albumin and assessed its prognostic values in ESCC patients treated with transthoracic esophagectomy. The presented data demonstrate that the preoperative DA score was significantly associated with postoperative survival and could act as an independent prognostic marker for ESCC patients. Furthermore, after stratification by TNM stage, the preoperative DA score remained of great prognostic value in patients with early-stage (stages I–IIA) and advanced-stage (stages IIB–IV) diseases. Therefore, according to the preoperative DA score, which was independent of TNM stage, we can preemptively identify patients who are at increased risk of recurrence and who would have poor prognosis postoperatively; thus, additional treatment, such as neoadjuvant chemotherapy and close follow-up, could be recommended.
GPS, an inflammation-based prognostic score, is widely recognized as a prognostic indicator for a variety of cancers, including liver, lung, breast, colorectal, and gastric cancers [24–27]. However, the clinical utility of GPS in EC patients remains controversial. Furthermore, some studies reported that inflammation and CRP levels are not commonly increased in ESCC patients . Therefore, we evaluated the use of plasma D-dimer levels as a replacement. D-dimer, a degradation product of fibrin, is an indicator of hypercoagulability and endogenous fibrinolysis. Recently, studies revealed that D-dimer associated with cellular signaling systems and could promote cell growth and induce angiogenesis . Buller et al.  reported that D-dimer could also induce the spread of tumors by stimulating tumor cells to adhere to endothelial cells. Moreover, Diao et al.  recently demonstrated that elevated plasma D-dimer level was associated with the progression of tumor and poor prognosis in EC, which was consistent with previous studies of colorectal, gastric, breast, and lung cancers [16, 23]. In addition, it is well accepted that malnutrition is a predictor of survival in cancer, and serum albumin is considered a nutritional indicator [20, 21]. Previous studies showed that hypoalbuminemia was associated with poor survival in numerous solid cancers, including gastrointestinal, lung, and breast cancers [19, 30]. Therefore, cumulative scores based on preoperative D-dimer and albumin levels may be a potentially predictive marker for prognosis of ESCC patients.
In recent years, some studies demonstrated that GPS was significantly associated with OS and DFS and could act as an independent prognostic marker for EC patients [31, 32]. In our study, preoperative GPS was also significantly predictive of OS in patients with ESCC (P = 0.037); however, the present data showed that only 1 patient had a GPS of 2, resulting in decreased benefit for predicting prognosis. As mentioned above, the severity of systemic inflammation and malnutrition in resectable EC might be insufficient to be effective as prognostic markers. Furthermore, multivariate analysis showed that GPS was not independently associated with OS or DFS. Matsuda et al.  reported similar results, of which only 2 of 199 EC patients were assigned a GPS score of 2, and GPS was shown to not be an independent prognostic factor for OS or DFS. The discordance in these studies might be explained by three factors. First, the difference of selected objects such as resectable and unresectable EC might lead to various results. Second, ethnicity and epidemiological differences may be the cause of the discrepancies between previous reports and our study. Third, whether the patients accepted neoadjuvant treatment may explain the observed discordance. In this study, the D-dimer and albumin optimal cutoffs were defined as 0.5 μg/mL and 43.8 g/L, respectively, according to ROC analysis, and preoperative D-dimer and albumin levels were both significantly associated with OS and DFS in ESCC patients (data not shown). Thus, we devised a novel prognostic scoring system called DA score and found that the preoperative DA score was significantly associated with age and family history of EC, whereas there was no association between the DA score and TNM stage, T category, or N category, indicating that the preoperative DA score reflected the patient’s individual status rather than tumor burden and progression. Kaplan–Meier analysis showed that patients with high preoperative DA scores had shorter OS and DFS compared with those with low preoperative DA scores. Multivariate analysis demonstrated that DA scores, along with age and TNM stage, were independent prognostic factors for postoperative survival. Therefore, preoperative DA score was superior to GPS as a predictive factor in ESCC patients treated with transthoracic esophagectomy.
We acknowledge that our study has the following limitations. First, our study was a retrospective study with a small sample size. Second, the present data were from a single institution. In addition, we did not include patients who underwent neoadjuvant treatment before surgery, which may have influenced our results.
In conclusion, our findings demonstrate that the preoperative DA score is associated with survival and can serve as an independent prognostic indicator in ESCC patients treated with transthoracic esophagectomy. We also conclude that DA score is superior to GPS as a predictive factor in patients with ESCC. Moreover, both plasma D-dimer and serum albumin are routinely measured in clinical practice, and the measurements are convenient, low-cost, and repeatable. Therefore, the DA score may be a simple and instructive indicator for the prognosis of ESCC patient in the future.
WHJ designed the study; DQL and FFL collected medical data and conducted statistical analysis; and DQL drafted the manuscript. All authors read and approved the final manuscript.
This work was supported by National Natural Science Funds for Distinguished Young Scholars (No. 81325018), the National Key Scientific and Technological Project (Grant No. 2011ZX09307-001-04), and the National Basic Research Program of China (No. 2011CB504303). Received: 4 Jun 2015 Accepted: 4 August 2015.
The authors declare that they have no conflicts of interest.
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