Open Access

Erratum to: Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver

Chinese Journal of Cancer201635:99

DOI: 10.1186/s40880-016-0156-5

Received: 3 November 2016

Accepted: 3 November 2016

Published: 28 November 2016

The original article was published in Chinese Journal of Cancer 2016 35:72

Erratum to: Chin J Cancer (2016) 35:72 DOI 10.1186/s40880-016-0138-7

After publication of this article [1], the editor noticed two errors in Figure 1. The word “Vemintin” should be “Vimentin” and “E-caderin” should be “E-cadherin”. The correct version of Fig. 1 can be found in this erratum.
Fig. 1

Schematic model of lymphocyte-specific helicase (LSH) in cancer progression. LSH promotes cell growth, migration, and invasion, which are characteristics of cancer progression. The effect of LSH is, in part, mediated by fumarate hydratase (FH), through the intact combination of LSH and euchromatic histone-lysine N-methyltransferase 2 (G9a). FH repression, in turn, leads to changes of tricarboxylic acid cycle (TCA) intermediates, including succinate, fumarate, and malate, and an increase in the ratio of α-ketoglutarate (α-KG) to fumarate. TCA intermediates promote migration, invasion, and epithelial–mesenchymal transition (EMT) through the decrease of E-cadherin and tight junction protein ZO-1 and the increase of vimentin. The changes of E-cadherin and ZO-1 are mediated by inhibitor of nuclear factor kappa-B kinase alpha (IKKα), which directly binds to these promoters

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Center for Medicine Research, Xiangya Hospital, Central South University
(2)
Cancer Research Institute, School of Basic Medicine, Central South University
(3)
Key Laboratory of Carcinogenesis and Cancer Invasion (Central South University), Ministry of Education

Reference

  1. Liu S, Tao YG. Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver. Chin J Cancer. 2016;35:72. doi:10.1186/s40880-016-0138-7.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s) 2016

Advertisement